Updated On Augby Ben Baker: Simply knowing which are the best weapons in Fallout 4 isn’t enough. While the player should always go with a weapon that matches their character’s strength and personal playstyle, it would be foolish to ignore the best weapons in Fallout 4. There are some weapons that rise to the top in terms of how destructive and useful they are in combat. Related: Fallout 4: Things Players Missed In The Castle Eventually, the player will be tossing aside weapons as they find bigger and badder tools of destruction. The great game Fallout 4 has a dizzying number of weapons for the player to find and modify in their efforts to recover their son and bring peace to the Commonwealth.